Single Nucleotide Polymorphism and Breast Cancer

Available online http:// converge-cancer-research.com/ fill/8/4/108 Commentary thaumaturgist nucleotide polymorphisms and breast cancer: not yet a succeeder story Rulla M Tamimi Channing Laboratory, surgical incision of Medicine, Brigham and Womens Hospital and Harvard Medical School, and De disassemblement of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA like author: Rulla Tamimi, rulla.tamimi@channing.harvard.edu Published: 27 July 2006 This article is online at http://breast-cancer-research.com/content/8/4/108 © 2006 BioMed Central Ltd Breast Cancer search 2006, 8:108 (doi:10.1186/bcr1529) Abstract chromosomal mutation and its impact on breast cancer systematically. Numerous studies study examined first stolid penetrance susceptibility polymorphisms in nominee genes, with some reporting real findings. However, for the most part these linkups could not be replicated in later(prenominal) studies, suggesting t hat the schoolmaster observations were due to chance [5]. In a pooled analysis of 46 necktie studies examining polymorphisms in 18 different genes, only ternion polymorphisms were significantly associated with breast cancer [5].

Despite considerable efforts make during the other(prenominal) few years to study genetic variation and breast cancer, on that point has been little success in identifying essential contributions to breast cancer. The inadequacy of robust and consistent findings from single SNP association studies led to the effusion of haplotype studies, which promised to examine more comprehensively the association between harsh genetic variation in view genes and risk for disease. This latest direction! of research efforts has also been more or less disappointing. Numerous studies have examined low penetrance susceptibility polymorphisms in candidate genes, with some reporting significant findings. However, for the most part these associations could not be replicated in subsequent studies, suggesting that the original...If you want to get a full essay, order it on our website: OrderEssay.net

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